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KMID : 0370220120560020108
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Yakhak Hoeji
2012 Volume.56 No. 2 p.108 ~ p.115
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Effects of Extacellular Divalent Cations on the Hyperpolarization-activated Currents in Rat Dorsal Root Ganglion Neurons
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Kwak Ji-Yeon
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Abstract
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The hyperpolarization-activated current () is an inward cation current activated by hyperpolarization of the membrane potential and plays a role as an important modulator of action potential firing frequency in many excitable cells. In the present study we investigated the effects of extracellular divalent cations on in dorsal root ganglion (DRG) neurons using whole-cell voltage clamp technique. was slightly increased in -free bath solution. BAPTA-AM did not change the amplitudes of . Amplitudes of were decreased by , and dose-dependently and voltage-independently. Inhibition magnitudes of by external divalent cations were partly reversed by the concomitant increase of extracellular concentration. Reversal potential of was significantly shifted by and was significantly affected by the changes of extracellular concentrations. These results suggest that is inhibited by extracellular divalent cations (, and ) by interfering ion influxes in cultured rat DRG neurons.
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KEYWORD
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divalent cations, DRG, hyperpolarization-activated currents, rat
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